Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Monoclonal Antibody(Clone: STAT3/2409)

Name: Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Monoclonal Antibody(Clone: STAT3/2409)
Brand: Abeomics
SKU: 36-3218
Price: 429.0000 USD
Availability: InStock
Rating: 4.5 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with STAT3 Mouse Monoclonal Antibody (STAT3/2409).

Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Monoclonal Antibody(Clone: STAT3/2409)

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Fig. 1: Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with STAT3 Mouse Monoclonal Antibody (STAT3/2409).

Fig. 2: SDS-PAGE Analysis Purified STAT3 Mouse Monoclonal Antibody (STAT3/2409). Confirmation of Integrity and Purity of Antibody.

Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using STAT3 Mouse Monoclonal Antibody (STAT3/2409). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-3218

Clone name :	STAT3/2409
Application :	IHC
Reactivity :	Human

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Download TDS MSDS

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Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	STAT3
Gene ID :	6774
Uniprot ID :	P40763
Alternative Name :	APRF; HIES; ADMIO; ADMIO1
Immunogen Information :	Recombinant human full-length STAT3 protein

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated throµgh phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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