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  7. 36-3673

Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)

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Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)

Fig. 1: Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Mouse Recombinant Monoclonal Antibody (rVEGI /1283).

Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)
Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)
Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)
Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)

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Fig. 1: Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Mouse Recombinant Monoclonal Antibody (rVEGI /1283).
   
Fig. 1: Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Mouse Recombinant Monoclonal Antibody (rVEGI /1283).
Fig. 2: Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Mouse Recombinant Monoclonal Antibody (rVEGI /1283).
Fig. 3: SDS-PAGE Analysis Purified VEGI Mouse Recombinant Monoclonal Antibody (rVEGI /1283). Confirmation of Purity and Integrity of Antibody.
Fig. 4: Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-3673

Clone name : rVEGI/1283
Application : IHC
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $199.00 

  • $429.00 

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  • Antigen Details
  • Description
  • Product Info
  • Application Note
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Gene : TNFSF15
Gene ID : 9966
Uniprot ID : O95150
Alternative Name : TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Immunogen Information : Recombinant human full-length VEGI protein
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody(Clone: rVEGI/1283)

Product code: 36-3673
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