Anti-von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Monoclonal Antibody(Clone: VWF/1859R)
Fig. 1: Formalin-fixed, paraffin-embedded human Tonsil stained with vWF Rabbit Recombinant Monoclonal Antibody (VWF/1859R).
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| Gene : | VWF |
| Gene ID : | 7450 |
| Uniprot ID : | P04275 |
| Alternative Name : | Coagulation Factor VIII, Factor VIII Related Antigen, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD) |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Immunogen Information : | Recombinant fragment of human vWF protein (aa1815-1939) (exact sequence is proprietary) |
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers althoµgh not all tumors of endothelial differentiation contain this antigen.
| Content : | 200 µg/ml of recombinant MAb Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
Western Blot (0.5-1.0µg/ml); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
