G alpha 15 Stable Cell Line-DP2-CHO-K1-Human
Figure 1: Functional analysis of DP2 receptor.
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| Amount : | 2 vials |
| Content : | Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO |
| Storage condition : | Immediately upon receipt, store in liquid nitrogen. |
| Alternative Name : | Human Recombinant Prostanoid Receptor DP2 Stable Cell Line |
Prostaglandin D(2) (PGD(2)) is derived from arachidonic acid and binds with high affinity to the G-protein coupled receptors prostanoid DP(1) and DP(2). Interaction with DP(2) results in cell chemotaxis, eosinophil degranulation, eosinophil shape change, adhesion molecule upregulation and Th2 cytokine production. In allergic rhinitis and allergic asthma PGD(2) is released from mast cells in response to allergen challenge and may trigger symptoms such as sneezing, rhinorrhea, pruritus, mucus hypersecretion and pulmonary inflammation. The cloned human DP2-expressing cell line co-expressing G alpha 15 is made in the CHO-K1 host.
Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: Hams F12, 10% FBS, 100 µg/ml Hygromycin B, 400 µg/ml G418
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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