Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Other Kits
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Recombinant Proteins
  4. /
  5. IL-2 Superkine (Fc) [IL-2 (human):Fc (human) (Recombinant)]

IL-2 Superkine (Fc) [IL-2 (human):Fc (human) (Recombinant)]

Share:

Figure 1: Binding of IL-2 Superkine (Fc) to IL-2R beta (human) is increased >10 fold compared to IL-2 (human):Fc (human) . Methods: IL-2R beta (human) was coated on an ELISA plate at 1µg/ml. After blocking and washing steps, indicated concentrations of IL-2 Superkine (Fc) or IL-2 (human):Fc (human) were added. Following incubation for 1 h at RT, the binding was detected using an anti-human Fc antibody (HRP).

IL-2 Superkine (Fc)  [IL-2 (human):Fc (human) (Recombinant)]

Roll over image to zoom in

   

Product code: 32-190051

Application : Functional Assay
Reactivity : Human

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS / Manual
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price
10 µg
$344.00 

Add to Wish List

Bulk Order

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS / Manual

  • Product Info
  • Description
  • Application Note
  • Review   (0)
Amount : 10 µg
Purification : >=95% (SDS-PAGE)
Content : Reconstitute with 100 µl sterile water.0.1mg/ml after reconstitution.
Lyophilized. Contains PBS.
Storage condition : Short Term Storage +4°C ; Long Term Storage-20°C ;After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0. 1% BSA should be used for further dilutions. Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
AA sequence : The extracellular domain of human IL-2 (aa 21-153) (mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F) is fused at the C-terminus to the Fc portion of human IgG2.
Alternative Name : IL-2 Superkine (human):Fc (human) (rec.); Interleukin-2; T Cell Growth Factor; TCGF; Aldesleukin; Super-2

Source :HEK 293 cells
Specific Binds to human and mouse IL-2R.Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
IL-2 promotes T cell proliferation and particularly naive T cells. IL-2 signaling on activated T cells is effected through a quaternary high-affinity receptor complex consisting of IL-2, IL-2Ralpha (CD25), IL-2Rbeta and IL-2Rgamma. Naive T cells are relatively insensitive to IL-2 as they only express small amounts of IL-2Rbeta and IL-2Rgamma. They only acquire sensitivity after CD25 expression, which captures the cytokine and presents it to the IL-2Rbeta and IL-2Rgamma receptors. IL-2 Superkine (Fc) is an artificial variant of IL-2 containing mutations at positions L80F / R81D / L85V / I 86V / I92F. These mutations are located in the molecule's core that acts to stabilize the structure and to give it a receptor-binding conformation mimicking native IL-2 bound to CD25. These mutations effectively eliminate the functional requirement of IL-2 for CD25 expression and elicit proliferation of T cells. Compared to IL-2, the IL-2 superkine induces superior expansion of cytotoxic T cells, leading to improved antitumour responses in vivo, and elicits proportionally less toxicity by lowering the expansion of Tregulatory cells and reducing pulmonary oedema.

MW :42kDa;
Biological ActivityTriggers T cell proliferation at concentration <10ng/ml in the presence of 250ng/mL each of anti-CD3 (ANC-144-020) and anti-CD28 (ANC-177-020) antibodies.
Endotoxin Content <0.01EU/µg protein (LAL test; Lonza).
Triggers far greater antitumor responses than native IL-2 in vivo but with lower toxicity.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Chicken IgY Control (Whole Molecule), Purified(Discontinued)

Chicken IgY Control (Whole Mol...

details-Chicken IgY Control (Whole Molecule), Purified(Discontinued)
Monoclonal Antibody to human CD14

Monoclonal Antibody to human C...

details-Monoclonal Antibody to human CD14
rhProcalcitonin Recombinant Protein

rhProcalcitonin Recombinant Pr...

details-rhProcalcitonin Recombinant Protein
TCF/LEF Leeporter™ Luciferase Reporter-HEK293 Cell Line

TCF/LEF Leeporter™ Luciferas...

details-TCF/LEF Leeporter™ Luciferase Reporter-HEK293 Cell Line
Recombinant human ROBO1 protein with C-terminal human Fc tag

Recombinant human ROBO1 protei...

details-Recombinant human ROBO1 protein with C-terminal human Fc tag
Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)

Monoclonal Antibody to Human C...

details-Monoclonal Antibody to Human CD51/CD61 (Integrin alpha v beta 3) NALE™ Purified (Clone: 23C6)
Mouse Monoclonal Antibody to Human RPL17 (Clone : 15B3F5)(Discontinued)

Mouse Monoclonal Antibody to H...

details-Mouse Monoclonal Antibody to Human RPL17 (Clone : 15B3F5)(Discontinued)
VISTA Stable Cell Line-H

VISTA Stable Cell Line-H

details-VISTA Stable Cell Line-H
Recombinant human Trop2 protein with C-terminal mouse Fc and 6×His tag

Recombinant human Trop2 protei...

details-Recombinant human Trop2 protein with C-terminal mouse Fc and 6×His tag
Monoclonal Antibody to mouse VCAM-1

Monoclonal Antibody to mouse V...

details-Monoclonal Antibody to mouse VCAM-1
Anti-PD-1 Monoclonal Antibody (Clone:IHC001)-Ready to Use

Anti-PD-1 Monoclonal Antibody ...

details-Anti-PD-1 Monoclonal Antibody (Clone:IHC001)-Ready to Use
IL-33 (oxidation resistant) (human) (Recombinant) (untagged)

IL-33 (oxidation resistant) (h...

details-IL-33 (oxidation resistant) (human) (Recombinant) (untagged)
Recombinant human RhoC protein with C-terminal human Fc tag

Recombinant human RhoC protein...

details-Recombinant human RhoC protein with C-terminal human Fc tag
Polyclonal Antibody to  Filaggrin-1

Polyclonal Antibody to  Filag...

details-Polyclonal Antibody to  Filaggrin-1

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin

Related Products

Recombinant Human Pro-Neuropeptide Y/NPY (C-6His)

Recombinant Human Pro-Neuropeptide Y/NPY (C-6His)

Recombinant Mouse Syndecan-Binding Protein 1/Syntenin-1/SDCBP (C-6His)

Recombinant Mouse Syndecan-Binding Protein 1/Syntenin-1/SDCBP (C-6His)

Recombinant Human RAB5B, Member RAS Oncogene Family

Recombinant Human RAB5B, Member RAS Oncogene Family

New Products

Anti-IL-1beta (Canakinumab biosimilar) mAb

Anti-IL-1beta (Canakinumab biosimilar) mAb

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Recombinant TLR5 Protein with human Fc Tag

Recombinant TLR5 Protein with human Fc Tag

close

Please Login to write a Review !!


close

IL-2 Superkine (Fc) [IL-2 (human):Fc (human) (Recombinant)]

Product code: 32-190051
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart