Monoclonal Antibody to CD11c (Clone: ABM4C58)
Fig-1: Cell surface flow analysis of hCD11C on human PBMCs using 1 µg/ 10^6 cells. Green represents isotype control (ABEOMICS); red represents anti-hCD11C antibody (10-7566). Goat anti-mouse FITC conjugated secondary antibody (ABEOMICS) was used. (Cells were incubated with primary antibody for 30 min. then washed twice with FLOW Staining buffer (ABEOMICS) by centrifuging at 1000 rpm for 5 min, followed by 30 min incubation with conjugated secondary antibody. Data acquisition was done after washing twice with FLOW staining buffer).
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|Amount :||100 µg|
|Isotype :||Mouse IgG2b Kappa|
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.|
CD11c/CD18 ( p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins (LPS, ICAM-1, ICAM-2, ICAM-4 and VCAM-1), extracellular matrix proteins (collagen I), and soluble ligands (iC3b, heparin and fibrinogen). It is expressed in macrophages, monocytes, granulocytes, subsets of T and B cells, and dendritic cells. CD11c functions as a cell surface receptor for numerous soluble factors and proteins. The interaction mediates leukocyte interactions with other cell types and is a signal transducing receptor. It is found primarily on myeloid cells, where its expression is regulated both during differentiation and during monocyte maturation into tissue macrophages.
Immunohistochemical analysis: 5-10 µg/ml
FACS: 0.5 - 1 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Tissue Specificity:||Predominantly expressed in monocytes and granulocytes.|
|BioGrid:||109893. 1 interactions.|
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