Monoclonal antibody to DR4 (Clone: ABM1B11 )

Fig.1: Intracellular FLOW analysis of Jurkat cells using 0.5 µgof DR4 antibody (Clone: ABM1B11). Isotype contol mouse IgG1 (ABEOMICS) was used. Goat Anti-mouse PE was used as secondary antibody.

Monoclonal antibody to DR4 (Clone: ABM1B11 )

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Fig.1: Intracellular FLOW analysis of Jurkat cells using 0.5 µgof DR4 antibody (Clone: ABM1B11). Isotype contol mouse IgG1 (ABEOMICS) was used. Goat Anti-mouse PE was used as secondary antibody.

Fig.2: Expression analysis of DR-4. Anti-DR4 antibody (Clone: ABM1B11) was tested at 2 µg/ml on K562 lysate.

Product code: 10-1002

Clone name :	ABM1B11
Clonality :	Monoclonal
Application :	FACS, WB
Reactivity :	Human

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Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1 Kappa
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	TNFRSF10A
Gene ID :	8797
Uniprot ID :	O00220
Alternative Name :	TNFRSF10A, APO2, DR4, TRAILR1
Immunogen Information :	A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody.

Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediates oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.

Western blot analysis: 2-4 µg/ml, FACS analysis- 0.5-1 µg/10^6 Cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Membrane
Tissue Specificity:	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
BioGrid:	114325. 50 interactions.