Monoclonal Antibody to Melanoma Marker (MART-1 + gp100 + Tyrosinase)(A103 + HMB45 + T311)

Product code: 36-11073

Clone name : A103 + HMB45 + T311
Clonality : Monoclonal
Application : WB, IHC
Reactivity : Human

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100 µg

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, kappa + Mouse IgG2a, kappa + Mouse IgG1, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MLANA
Gene ID : 2315
Uniprot ID : Q16655
Alternative Name : MLANA, MART1
Immunogen Information : Recombinant hMART-1 protein (A103); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. The function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Western Blot (2-4ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus, Melanosome
Post transnational modification: Acylated.
Tissue Specificity: Expression is restricted to melanoma and melanocyte cell lines and retina.
BioGrid: 108604. 2 interactions.
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