Monoclonal Antibody to mouse MD-1 (Clone : MD113)
|Amount :||500 µg|
|Isotype :||Rat IgG2b|
|Content :||0.5 mg, 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.|
|Storage condition :||Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.|
The monoclonal antibody 10-3503 reacts with mouse MD-1. MD-1 (22-25 kD) is an extracellular protein associated with the extracellular domain of RP105. The latter is a type 1 transmembrane protein with leucine-rich repeats. RP105 is similar to Drosophila Toll. MD-1 associated with RP105 (similar to TLR4/MD-2) appears to be an essential molecule that helps RP105 on B-cells to signal to LPS. The MD113 antibody is antagonistic in LPS-induced B-cell proliferation and B7.2 up-regulation.
The monoclonal antibody MD113 can be used for flow cytometry and functional studies. The monoclonal antibody cannot be used for Western blot and immunoprecipitation.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
1: Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, Shively JE. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol. 2019 Jan 23;20(1):7. doi: 10.1186/s12865-019-0287-y. PubMed PMID: 30674283; PubMed Central PMCID: PMC6345024.
|Tissue Specificity:||Highly expressed in spleen, liver, brain and thymus, and at lower levels in kidney.|