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    7. Monoclonal Antibody to p57Kip2 (Mitotic Inhibitor/Suppressor Protein)(Clone : KP10)

    Monoclonal Antibody to p57Kip2 (Mitotic Inhibitor/Suppressor Protein)(Clone : KP10)

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    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with p57 Monoclonal Antibody (KP10).

    Monoclonal Antibody to p57Kip2 (Mitotic Inhibitor/Suppressor Protein)(Clone : KP10)

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    Product code: 36-1013

    Clone name : KP10
    Clonality : Monoclonal
    Application : IHC
    Reactivity : Human, Mouse

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    Size
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    100 µg
    $499.00 

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    Shipping Info:

    For estimated delivery dates, please contact us at support@abeomics.com

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    • Product Info
    • Antigen Details
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    Format : Purified
    Amount : 100 µg
    Isotype : Mouse IgG2b, kappa
    Purification : Affinity Chromatography
    Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
    Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : CDKN1C
    Gene ID : 1028
    Uniprot ID : P49918
    Alternative Name : CDKN1C, KIP2
    Immunogen Information : Recombinant human p57Kip2 protein
    Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

    Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Nucleus
    Tissue Specificity: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
    BioGrid: 107462. 21 interactions.
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    Monoclonal Antibody to p57Kip2 (Mitotic Inhibitor/Suppressor Protein)(Clone : KP10)

    Product code: 36-1013
    *specify in mg or ml

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