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  7. Monoclonal Antibody to TLR4 (Clone : 3C3)

Monoclonal Antibody to TLR4 (Clone : 3C3)

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Figure-1: Functional study of human TLR4/MD-2 antibodies on TNF production in a whole blood model upon treatment with LPS 10 ng/ml.

Monoclonal Antibody to TLR4 (Clone :  3C3)

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Product code: 10-3522

Clone name : 3C3
Clonality : Monoclonal
Application : Functional Assay, FACS
Reactivity : Human

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  •   100 µg

  •  500 µg

  • $754.00 

  • $1,745.00 

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Format : Purified
Amount : 500 µg
Isotype : Mouse IgG1
Content : 0.5 mg, 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Storage condition : Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Gene : TLR4
Gene ID : 7099
Uniprot ID : O00206
Immunogen Information : CHO cells expressing chimeric human TLR4/MD-2 fusion protein

The monoclonal antibody 10-3522 reacts with human Toll-like receptor 4 (TLR4, CD284). TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria. The monoclonal antibody 3C3 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells.

Subcellular location: Cell membrane
Post transnational modification: N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
Tissue Specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
BioGrid: 112954. 31 interactions.
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Monoclonal Antibody to TLR4 (Clone : 3C3)

Product code: 10-3522
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