Monoclonal Antibody to TOX-3 (Clone: ABM44A1)
|Amount :||100 µg|
|Isotype :||Mouse IgG1 Kappa|
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
TOX high mobility group box family member 3 (TOX-3) is a member of a subfamily of transcription factors that contains a High Mobility Group box (HMG-box), involved in bending and unwinding of DNA and alteration of chromatin structure. It has two transcript variants encoding different isoforms.TOX3 is expressed in estrogen receptor-positive mammary epithelial cells, including progenitor cells and highly expressed in luminal B breast cancers. Its over expression in human oligodendrocytes reduced cellular death under conditions mimicking Spinal cord injury (SCI).
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Tissue Specificity:||Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.|
|BioGrid:||118139. 2 interactions.|