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  7. P2Y6 Stable Cell Line-1321N1-Human(Currently Unavailable)

P2Y6 Stable Cell Line-1321N1-Human(Currently Unavailable)

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Figure 1: Functional analysis of P2Y6 receptor.

P2Y6 Stable Cell Line-1321N1-Human(Currently Unavailable)

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Product code: 14-6154ACL

Application : Functional Assay
Reactivity : Human

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Amount : 2 vials
Content : Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO
Storage condition : Immediately upon receipt, store in liquid nitrogen.
Alternative Name : Human Recombinant P2Y6 Purinergic Receptor Stable Cell Line
P2Y receptors are one of three families of extracellular receptors for purine and pyrimidine nucleotides involved in purinergic signaling. In heterologous expression systems, recombinant P2Y1, P2Y2, P2Y4, P2Y6 receptors couple to G proteins (mainly Gq) which, in turn, activate intracellular signaling cascades - mainly the phospholipase C beta (PLC beta ) isoform to mobilise intracellular Ca2+ ions. RT-PCR and Northern Blotting studies show a high expression of this receptor in spleen and placenta, followed by kidney, adipose, bone, lung, heart, brain and skeletal muscle. In mouse bone marrow-derived mast cells (mBMMCs) and in the human MC line LAD2, P2Y6 receptors cooperate with CysLT1R to promote cell survival and chemokine generation by a pathway involving reciprocal ligand-mediated cross-talk. In human, rat and mouse, P2Y6 expression is increased by the stress associated with intestinal inflammation, leading to the release of CXC chemokine ligand 8. In rabbit, the receptor functions by increasing osteoclast survival through the NFkB pathway.

Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: DMEM, 10% FBS, 250 µg/ml G418

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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P2Y6 Stable Cell Line-1321N1-Human(Currently Unavailable)

Product code: 14-6154ACL
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