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    7. Polyclonal Antibody to MUM1

    Polyclonal Antibody to MUM1

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    Fig-1: Expression analysis of MUM1. Anti-MUM1 antibody (11-7551) was used at 1 µg/ml on (1) Jurkat and (2) Ramos lysates.

    Polyclonal Antibody to MUM1

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    Product code: 11-7551

    Clonality : Polyclonal
    Application : WB
    Reactivity : Human

    Shipping Info:

    Order now and get it on Friday August 12, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Local delivery areas

    Same-day delivery in San Diego available for the following zip codes:

    92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
    Download TDS MSDS
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    Size
    Price

    Available Pack Size(s)

    •   25 µg

    •  100 µg

    • $90.00 

    • $260.00 

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    Shipping Info:

    Order now and get it on Friday August 12, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Download TDS MSDS

    • Product Info
    • Antigen Details
    • Description
    • Application Note
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    • Review   (0)
    Format : Purified
    Amount : 100 µg
    Isotype : Rabbit IgG
    Purification : Protein A Chromatography
    Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
    Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : MUM1
    Gene ID : 84939
    Uniprot ID : Q2TAK8
    Alternative Name : MUM1, EXPAND1
    Immunogen Information : A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.
    MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential diagnosis of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.

    Western blot analysis: 1-2 µg/ml

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Nucleus
    BioGrid: 124373. 14 interactions.
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    Polyclonal Antibody to MUM1

    Product code: 11-7551
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