Polyclonal Antibody to Tubulin beta-III
Figure 1: Western blot analysis of extract from Mouse brain tissue, Hela, JK and P19 cells using Tubulin beta-III Antibody 35-1787
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the a-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Predicted MW: 55kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
1. Filippi K, Riße I, Judge LM, Conklin BR, Fleischmann BK, Hesse M.
Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with BAG3 P209L myofibrillar myopathy-6.
Stem Cell Res. 2025 Aug;86:103718. doi: 10.1016/j.scr.2025.103718. Epub 2025 Apr 21.
PMID: 40318522
2. Filippi K, Wiemann M, Rupp S, Peitz M, Fleischmann BK, Hesse M.
Generation of human induced pluripotent stem cell (iPSC) lines from two patients with BAG3 P209L myofibrillar myopathy-6.
Stem Cell Res. 2025 Aug;86:103712. doi: 10.1016/j.scr.2025.103712. Epub 2025 Apr 12.
PMID: 40252588 Free article.
3. Filippi K, Wiemann M, Fleischmann BK, Hesse M.
Generation of two isogenic control lines by correcting the BAG3 P209L mutation of human induced pluripotent stem cell (hiPSC) lines from patients with myofibrillar myopathy-6.
Stem Cell Res. 2025 Feb;82:103627. doi: 10.1016/j.scr.2024.103627. Epub 2024 Dec 7.
PMID: 39662463 Free article.
4. Riße I, Filippi K, Wiemann M, Fleischmann BK, Hesse M.
Generation of an isogenic series of genome-edited hiPSC lines with the BAG3(P209L)-mutation for modeling myofibrillar myopathy 6.
Stem Cell Res. 2025 Feb;82:103641. doi: 10.1016/j.scr.2024.103641. Epub 2024 Dec 21.
PMID: 39729860 Free article.
5. Kerstin Filippi 1, Isabelle Riße 1, Luke M Judge 2, Bruce R Conklin 2, Bernd K Fleischmann 1, Michael Hesse 3
Generation and characterization of an isogenic control line by correcting the BAG3 P209L mutation of a human induced pluripotent stem cell (hiPSC) line from a patient with myofibrillar myopathy-6
Stem Cell Res. 2025 Feb:82:103626. doi: 10.1016/j.scr.2024.103626. Epub 2024 Dec 9.
PMID: 39662461
6. Zhang Y, Peitz M, Fleischmann BK, Rieck S.
Generation of a genome-edited EMILIN1 (c.1606C>T) hiPSC line to investigate aortic aneurysm formation in vitro.
Stem Cell Res. 2025 Aug;86:103708. doi: 10.1016/j.scr.2025.103708. Epub 2025 Apr 5.
PMID: 40222083.
7. Triantafyllou C, Peitz M, Fleischmann BK, Rieck S.
Generation of a homozygous DNMT3A knock-out hiPSC line for modeling of cardiovascular diseases associated with clonal hematopoiesis of indeterminate potential.
Stem Cell Res. 2025 Aug;86:103707. doi: 10.1016/j.scr.2025.103707.
Epub 2025 Apr 5. PMID: 40311329.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. |
| Tissue Specificity: | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. |
| BioGrid: | 115654. 280 interactions. |
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