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  5. Recombinant human CTLA-4 protein with C-terminal human Fc tag

Recombinant human CTLA-4 protein with C-terminal human Fc tag

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Figure 1. Human CTLA-4 Protein, hFc Tag on SDS-PAGE under reducing condition.

Recombinant human CTLA-4 protein with C-terminal human Fc tag
Recombinant human CTLA-4 protein with C-terminal human Fc tag
Recombinant human CTLA-4 protein with C-terminal human Fc tag

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Figure 1. Human CTLA-4 Protein, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CTLA-4, hFc tagged protein  can bind Anti-CTLA4 Neutralizing antibody in a linear range of 0.64-80.0 ng/ml.
Figure 3. HEK293 cell line transfected with irrelevant protein (B) and human B7-2 (A) were surface stained with Human CTLA4, hFc tagged protein  1µg/ml followed by Alexa 488-conjugated anti-human IgG secondary antibody.

Product code: 32-17091

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50 µg
$551.00 

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Amount : 50 µg
Purification : The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage condition : Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Alternative Name : CTLA4, CD152
Expression Host : HEK293
The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide.The apparent molecular mass of CTLA4-hFC is approximately 40-55 kDa due to glycosylation.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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Recombinant human CTLA-4 protein with C-terminal human Fc tag

Product code: 32-17091
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