Recombinant Human IL-13 Variant(Discontinued)

Source:E.coli
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1Beta, TNF-Alpha, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 are cross-species reactive.  A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. The genetic variant, termed Recombinant Human IL-13 Variant, is a mature 115 amino acid protein with a substitution of Q for R at position 112.  The calculated molecular weight of Recombinant Human IL-13 Variant is 12.6 kDa.

This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitrodose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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