Human CD80 Recombinant Fc fusion Protein (Active)
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|Amount :||100 µg|
|Purification :||95% Purity SDS-PAGE and HPLC|
|Content :||Lyophilized from sterile PBS, 5% trehalose and 0.01% tween 80 are added as protectant before lyophilization. Reconstitutes sterile water.|
|Storage condition :||Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|AA sequence :||Human CD80 (ECD): MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKE VATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYK NRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLA EVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWL ENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKY GHLRVNQTFNWNTTKQEHFPDN|
|Alternative Name :||T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD28LG, CD28LG1, LAB7|
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. Cancer Immunotherapy Co- inhibitory Immune Checkpoint Targets Immune Checkpoint Immune Checkpoint Detection
Human extracellular domain CD80 (B7-1) Fc fusion protein. This protein is expressed in CHO-K1 cells and purified using protein G colomn. Protein MW 53 kDa but SDS it runs arround 65 kDa due to glycosylation.
Measured by its binding ability in a functional FLOW assay. Binding assay was tested using CHO-K1/CTLA4 cell line (cat no. 14-506ACL).
Endotoxin: <1.0EU per ug of the protein as determin by the LAL method.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.