SARS-CoV-2 Inhibitor Screening Kit

Product code: 17-3001

Application : Functional Assay

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6 × 16 Tests

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Amount : 6 × 16 Tests
Content : 6x16 well Format (96 tests)
Storage condition : Please refer to the Manual
Alternative Name : COVID-19 Inhibitor Screening Kit; 2019-nCoV Inhibitor Screening Kit; 2019-nCoV Spike Protein S1 (RBD)/ACE2 Inhibitor Screening Kit

Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many other wild animals. Recently, a new severe acute respiratory syndrome β-coronavirus called SARS-CoV-2 (or 2019-nCoV) has emerged, which causes an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19).SARS-CoV-2 contains 4 structural proteins, including Envelope (E), Membrane (M), Nucleocapsid (N) and Spike (S), which is a transmembrane protein, composed of two subunits S1 and S2. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor. Angiotensin-Converting Enzyme 2 (ACE2) present at the surface of epithelial cells, causing mainly infection of human respiratory cells. 

This inhibitor screening assay is based on a colorimetric ELISA kit, which measures the binding of the RBD of the Spike S protein from SARS-CoV-2 to its human receptor ACE2. Thus, this assay allows to identify and characterize the effect of different inhibitory molecules including antibodies or chemicals on the inhibition of the binding of SARS-CoV-2 virus to human ACE2. 

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Hameed, Noor S.; Arif, Inam Sameh; Al-Sudani, Basma Talib
Preventive treatment of coronavirus disease-2019 virus using coronavirus disease-2019-receptor-binding domain 1C aptamer by suppress the expression of angiotensin-converting enzyme 2 receptor.
Journal of Advanced Pharmaceutical Technology & Research 14(3):p 185-190, Jul–Sep 2023

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