Anti-BCMA bispecific antibody(DM4)
|Amount :||100 µg|
|Isotype :||Rabbit scfv|
|Purification :||Purified from cell culture supernatant by affinity chromatography|
|Content :||Preservative: 0.1% Procline 300
Constituents: 50% Glycerol; PBS, pH 7.4; 0.1% BSA
|Storage condition :||Store at -20°C for 12 months (Avoid repeated freezing and thawing)|
|Alternative Name :||TNFRSF17, CD269, BCM, BCMA|
|Immunogen Information :||Recombinant human BCMA (Met1-Ala54) produced by using human HEK293 cells|
BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Recommended Dilutions FACS 1/100; MMTumor cell killing
For Research Use Only. Not for use in diagnostic/therapeutics procedures.