Anti-CD148 Monoclonal Antibody (Clone:MEM-CD148/05)-APC Conjugated

Product code: 30-1806

Clone name : MEM-CD148/05
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : APC

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100 tests

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Amount : 100 tests
Isotype : Mouse IgG2b
Content : PBS + 0.05% sodium Azide
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : PTPRJ
Gene ID : 5795
Uniprot ID : Q12913
Alternative Name : PTPRJ, DEP1
Immunogen Information : Human recombinant CD148 (amino acids 1-444)

CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.

Subcellular location: Cell membrane, Cell projection, Cell junction
Post transnational modification: N- and O-glycosylated.
Tissue Specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
BioGrid: 111759. 30 interactions.
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