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    7. Anti-CD148 Monoclonal Antibody (Clone:MEM-CD148/05)-APC Conjugated

    Anti-CD148 Monoclonal Antibody (Clone:MEM-CD148/05)-APC Conjugated

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    Figure 1: Surface staining of human peripheral blood using anti-CD148 (MEM-CD148/05) APC.

    Anti-CD148 Monoclonal Antibody (Clone:MEM-CD148/05)-APC Conjugated

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    Product code: 30-1806

    Clone name : MEM-CD148/05
    Clonality : Monoclonal
    Application : FACS
    Reactivity : Human
    Conjugate : APC

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    100 tests
    $418.00  $334.40 

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    Amount : 100 tests
    Isotype : Mouse IgG2b
    Content : PBS + 0.05% sodium Azide
    Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
    Gene : PTPRJ
    Gene ID : 5795
    Uniprot ID : Q12913
    Alternative Name : PTPRJ, DEP1
    Immunogen Information : Human recombinant CD148 (amino acids 1-444)

    CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.

    Subcellular location: Cell membrane, Cell projection, Cell junction
    Post transnational modification: N- and O-glycosylated.
    Tissue Specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
    BioGrid: 111759. 30 interactions.
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    Anti-CD148 Monoclonal Antibody (Clone:MEM-CD148/05)-APC Conjugated

    Product code: 30-1806
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