Anti-CD195 / CCR5 Monoclonal Antibody (Clone:T21/8) Biotin Conjugated

Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD195 (T21/8) biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
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Amount : | 0.1 mg |
Isotype : | Mouse IgG1 kappa |
Purification : | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
Content : | Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
Description: CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.
Flow cytometry: Recommended dilution: 1-5 μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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