Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)
Figure 1: Intracellular staining of CD22 in human immature B cells with anti-CD22 (S-HCL-1) APC.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated on tyrosine residues by LYN. |
| Tissue Specificity: | B-lymphocytes. |
| BioGrid: | 107371. 15 interactions. |
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