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    7. Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)

    Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)

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    Figure 1: Intracellular staining of CD22 in human immature B cells with anti-CD22 (S-HCL-1) APC.

    Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)

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    Product code: 30-1675

    Clone name : S-HCL-1
    Clonality : Monoclonal
    Application : FACS
    Reactivity : Human
    Conjugate : APC

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    Shipping Info:

    For estimated delivery dates, please contact us at support@abeomics.com

    Download TDS MSDS

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    • Antigen Details
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    Amount : 100 tests
    Isotype : Mouse IgG2b
    Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
    Gene : CD22
    Gene ID : 933
    Uniprot ID : P20273
    Alternative Name : CD22, SIGLEC2
    Immunogen Information : Whole hairy cell leukemia cells and membrane preparation

    CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

    Subcellular location: Cell membrane
    Post transnational modification: Phosphorylated on tyrosine residues by LYN.
    Tissue Specificity: B-lymphocytes.
    BioGrid: 107371. 15 interactions.
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    Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)

    Product code: 30-1675
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