Anti-CD22 Monoclonal Antibody (Clone:S-HCL-1)-APC Conjugated(Discontinued)
|Amount :||100 tests|
|Isotype :||Mouse IgG2b|
|Storage condition :||Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.|
CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
|Subcellular location:||Cell membrane|
|Post transnational modification:||Phosphorylated on tyrosine residues by LYN.|
|BioGrid:||107371. 15 interactions.|