Anti-CD49c / Integrin alpha 3 Monoclonal Antibody (Clone:ASC-1)

Product code: 30-1061

Clone name : ASC-1
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg

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For estimated delivery dates, please contact us at [email protected]

Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ITGA3
Gene ID : 3675
Uniprot ID : P26006
Alternative Name : ITGA3, MSK18
Immunogen Information : Human SSC-9 cell line (squamous cell carcinoma)

CD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen). It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells.

Subcellular location: Cell membrane, Cell membrane, Cell projection, Cell projection
Post transnational modification: Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
BioGrid: 109882. 16 interactions.
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