Anti-CD64 / FcgammaRI Monoclonal Antibody (Clone:10.1)

CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo.

Flow Cytometry Recommended dilution:5 µg/ml
Immunoprecipitation Western Blotting Immunohistochemistry Application note:There can occur problems with paraformaldehyde fixation Immunohistochemistry (frozen sections) Application note:There can occur problems with paraformaldehyde fixation Immunocytochemistry Functional Application blocking of IgG binding to the FcgammaR1

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane
Post transnational modification:	Phosphorylated on serine residues.
Tissue Specificity:	Monocyte/macrophage specific.
BioGrid:	108503. 20 interactions.

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