Anti-StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker) Monoclonal Antibody(Clone: STAR/2140)
Fig. 1: Formalin-fixed, paraffin-embedded human Adrenal Gland stained with StAR Mouse Monoclonal Antibody (STAR/2140).
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2b, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | STAR |
| Gene ID : | 6770 |
| Uniprot ID : | P49675 |
| Alternative Name : | Cholesterol trafficker; Luteinizing hormone induced protein; Mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StARD1; START domain-containing protein 1; Steroid acute regulatory protein; Steroidogenic acute regulator (STAR); Steroidogenic acute regulatory protein mitochondrial |
| Immunogen Information : | Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary) |
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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