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    7. Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)

    Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)

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    Figure 1: Immunohistochemical analysis of CTLA-4 (Clone: IHC004) on Tonsil

    Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)

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    Product code: 44-1023

    Clone name : IHC004
    Clonality : Monoclonal
    Application : IHC
    Reactivity : Human

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    7 ml
    $519.00  $415.20 

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    • Antigen Details
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    Format : Purified
    Amount : 7 ml
    Purification : Protein A/G Chromatography
    Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
    Storage condition : Store at 2°C - 8°C. Do not freeze.
    Gene : CTLA4
    Gene ID : 1493
    Uniprot ID : P16410
    Alternative Name : CTLA4, CD152
    Immunogen Information : Recombinant Human CTLA-4

    Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a receptor on T Helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto’s thyroiditis, Graves’ disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient’s serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration).

    Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cell membrane
    Post transnational modification: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
    Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
    BioGrid: 107875. 109 interactions.
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    Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)

    Product code: 44-1023
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