Anti-HNF1A (Pancreatic Tumor Suppressor) Monoclonal Antibody(Clone: HNF1A/2087)
Fig. 1: Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | HNF1A |
| Gene ID : | 6927 |
| Uniprot ID : | P20823 |
| Alternative Name : | Albumin proximal factor; Hepatic nuclear factor 1 alpha; Hepatic transcription factor 1 alpha; HNF-1A; Interferon production regulator factor; LFB1; LFB1 hepatic nuclear factor; Liver specific transcription factor LFB1; Maturity onset diabetes of the young 3 (MODY3); TCF1; Transcription factor 1 hepatic |
| Immunogen Information : | Recombinant fragment (around aa 214-339) of human HNF1A protein (exact sequence is proprietary) |
HNF1A belongs to the homeobox protein family and is an essential transcription factor for many hepatic genes involved in detoxification, homeostasis and metabolisms of glucose, lipid, steroid and amino acid. In addition, HNF1A is an important component of the transcriptional networks governing embryonic pancreas development and differentiation. as well as maintaining the growth and function of islet cells in adult. HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas. Recently, genome-wide association studies have implicatedHNF1Aas a susceptibility gene for pancreatic cancer.
ELISA (For coating, order antibody without BSA);Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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