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  7. Monoclonal Antibody to TLR4 / CD284 (Clone: ABM19C4) FITC Conjugated

Monoclonal Antibody to TLR4 / CD284 (Clone: ABM19C4) FITC Conjugated

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Fig-1 :Flow analysis of human TLR4 antibody (Clone:ABM19C4): Cell surface staining of PBMC, Red represents hTLR4 FITC, Green represents Isotype control mouse IgG2b FITC. 0.5 ug antibody was used.

Monoclonal Antibody to TLR4 / CD284 (Clone: ABM19C4) FITC Conjugated

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Product code: 10-3010-F

Clone name : ABM19C4
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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Order now and get it on Tuesday January 19, 2021

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Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $90.00 

  • $270.00 

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Order now and get it on Tuesday January 19, 2021

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  • Product Info
  • Antigen Details
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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b Kappa
Purification : Protein G Chromatography
Content : 0.2 mg/ml in Tris buffer and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months.
Gene : TLR4
Gene ID : 7099
Uniprot ID : O00206
Alternative Name : TLR4
Immunogen Information : A partial length recombinant TLR4 protein (amino acids 45-320) was used as the immunogen for this antibody.

TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.

FACS analysis: 2-4 µg/10^6

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
Tissue Specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
BioGrid: 112954. 31 interactions.
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Monoclonal Antibody to TLR4 / CD284 (Clone: ABM19C4) FITC Conjugated

Product code: 10-3010-F
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