Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
        • Primary Cells
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Antibodies
  4. /
  5. Cancer Marker
  6. /
  7. Anti-MLH1 (MutL Homolog 1) Monoclonal Antibody(Clone: MLH1/1324)

Anti-MLH1 (MutL Homolog 1) Monoclonal Antibody(Clone: MLH1/1324)

Share:

Fig. 1: SDS-PAGE Analysis Purified MLH1 Mouse Monoclonal Antibody (MLH1/1324). Confirmation of Integrity and Purity of Antibody

Anti-MLH1 (MutL Homolog 1) Monoclonal Antibody(Clone: MLH1/1324)

Roll over image to zoom in

   

Product code: 36-2776

Clone name : MLH1/1324
Clonality : Monoclonal
Application : ELISA
Reactivity : Human

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   20 µg

  •  100 µg

  • $199.00 

  • $459.00 

Add to Wish List

Bulk Order

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • Application Note
  • Review   (0)
Amount : 100 µg
Isotype : Mouse IgG2b, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : MLH1
Gene ID : 4292
Uniprot ID : P40692
Alternative Name : COCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; MutL homolog 1 (E. coli); MutL homolog 1 (MLH1); MutL homolog 1 colon cancer nonpolyposis type 2 (HNPCC2); MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); MutL protein homolog 1; MutL, E. coli, homolog of, 1
Immunogen Information : Recombinant human MLH1 protein
This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, sµggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

ELISA (Use Ab at 2-4µg/ml for coating) (Order Ab without BSA); Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Anti-Mammaglobin (SCGB2A2) (Breast Cancer Marker) Monoclonal Antibody(Clone: MGB1/2123R)

Anti-Mammaglobin (SCGB2A2) (Br...

details-Anti-Mammaglobin (SCGB2A2) (Breast Cancer Marker) Monoclonal Antibody(Clone: MGB1/2123R)
Anti-CD10 (Membrane Metalloendopeptidase) Monoclonal Antibody(Clone: 56C6)

Anti-CD10 (Membrane Metalloend...

details-Anti-CD10 (Membrane Metalloendopeptidase) Monoclonal Antibody(Clone: 56C6)
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/3398)

Anti-Nucleophosmin (Acute Myel...

details-Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/3398)
Anti-Renalase (Renal Cell Marker) Monoclonal Antibody(Clone: RNLS/1940)

Anti-Renalase (Renal Cell Mark...

details-Anti-Renalase (Renal Cell Marker) Monoclonal Antibody(Clone: RNLS/1940)
Anti-Malate dehydrogenase 1 NAD (soluble) Monoclonal Antibody(Clone: CPTC-MDH1-1)

Anti-Malate dehydrogenase 1 NA...

details-Anti-Malate dehydrogenase 1 NAD (soluble) Monoclonal Antibody(Clone: CPTC-MDH1-1)
Anti-MBD1 (Methyl-CpG Binding Domain Protein 1) Monoclonal Antibody(Clone: CPTC-MBD1-1)

Anti-MBD1 (Methyl-CpG Binding ...

details-Anti-MBD1 (Methyl-CpG Binding Domain Protein 1) Monoclonal Antibody(Clone: CPTC-MBD1-1)
Anti-MUC5AC (Mucin 5AC / Gastric Mucin) Monoclonal Antibody(Clone: 2-11M1)

Anti-MUC5AC (Mucin 5AC / Gastr...

details-Anti-MUC5AC (Mucin 5AC / Gastric Mucin) Monoclonal Antibody(Clone: 2-11M1)
Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)

Anti-DOG-1 / TMEM16A (Gastroin...

details-Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody(Clone: DG1/1486)
SARS-CoV-2 Spike S1 Mutant Sampler Set

SARS-CoV-2 Spike S1 Mutant Sam...

details-SARS-CoV-2 Spike S1 Mutant Sampler Set
Anti-MCM7 (Proliferation Marker) Monoclonal Antibody(Clone: MCM7/1467)

Anti-MCM7 (Proliferation Marke...

details-Anti-MCM7 (Proliferation Marker) Monoclonal Antibody(Clone: MCM7/1467)
Anti-MRP1 / ABCC1 (Multidrµg Resistance Related Protein 1) Monoclonal Antibody(Clone: MRP1/1343)

Anti-MRP1 / ABCC1 (Multidrµg ...

details-Anti-MRP1 / ABCC1 (Multidrµg Resistance Related Protein 1) Monoclonal Antibody(Clone: MRP1/1343)
Anti-BOB.1 (B-Cell Marker) Monoclonal Antibody(Clone: BOB1/2425)

Anti-BOB.1 (B-Cell Marker) Mon...

details-Anti-BOB.1 (B-Cell Marker) Monoclonal Antibody(Clone: BOB1/2425)
Anti-ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody(Clone: 23c)

Anti-ATRX / RAD54 (Alpha Thala...

details-Anti-ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody(Clone: 23c)
Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody(Clone: PAPPA/2718)

Anti-PAPP-A / Pappalysin-1 (Ma...

details-Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody(Clone: PAPPA/2718)

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Peroxidase conjugated Goat anti Mouse IgG (H+L)

Peroxidase conjugated Goat anti Mou...

details-Peroxidase conjugated Goat anti Mouse IgG (H+L)

Related Products

Monoclonal Antibody to CD99 / MIC2 (Ewing's Sarcoma Marker)(Clone : SPM586)

Monoclonal Antibody to CD99 / MIC2 (Ewing's Sarcoma Marker)(Clone : SPM586)

Anti-TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Monoclonal Antibody(Clone: TRAF1/3298)

Anti-TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Monoclonal Antibody(Clone: TRAF1/3298)

Anti-CD71 / Transferrin Receptor (TFRC) Monoclonal Antibody(Clone: TFRC/1149)

Anti-CD71 / Transferrin Receptor (TFRC) Monoclonal Antibody(Clone: TFRC/1149)

New Products

Recombinant Human Cysteine-Rich Secretory Protein 3/CRISP-3/SGP28 (C-6His)

Recombinant Human Cysteine-Rich Secretory Protein 3/CRISP-3/SGP28 (C-6His)

Phospho-S6-Ribosomal Protein (Ser240/244) (Clone: CD10) rabbit mAb FITC Conjugate

Phospho-S6-Ribosomal Protein (Ser240/244) (Clone: CD10) rabbit mAb FITC Conjugate

Phospho-Lyn (Tyr507) (Clone: 5B6) rabbit mAb FITC conjugate

Phospho-Lyn (Tyr507) (Clone: 5B6) rabbit mAb FITC conjugate

close

Please Login to write a Review !!


close

Anti-MLH1 (MutL Homolog 1) Monoclonal Antibody(Clone: MLH1/1324)

Product code: 36-2776
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2021 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart