Anti-PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Monoclonal Antibody(Clone: PDL1/2746)
|Gene ID :||29126|
|Uniprot ID :||Q9NZQ7|
|Alternative Name :||B7 homolog 1; B7-H1; CD274; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; Programmed cell death 1 ligand 1|
|Amount :||0.5 ml at 100µg/ml|
|Isotype :||Mouse IgG2b, kappa|
|Immunogen Information :||Recombinant fragment (around aa 39-191) of human CD274 (PD-L1) protein (exact sequence is proprietary)|
PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.
|Content :||200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage condition :||Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous.|
Flow Cytometry (1-2µg/million cells); ,Immunofluorescence (1-2µg/ml);Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.