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  7. Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)

Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)

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Fig. 1: SDS-PAGE Analysis Purified TYMS Recombinant Mouse Monoclonal Antibody (rTYMS/1884). Confirmation of Purity and Integrity of Antibody.

Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)
Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)

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Fig. 1: SDS-PAGE Analysis Purified TYMS Recombinant Mouse Monoclonal Antibody (rTYMS/1884). Confirmation of Purity and Integrity of Antibody.
Fig. 2: Flow Cytometric Analysis of PFA-fixed MOLT4 cells. TYMS Recombinant Mouse Monoclonal Antibody (rTYMS/1884) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Product code: 36-3324

Clone name : rTYMS/1884
Clonality : Monoclonal
Application : ELISA, FACS, IF
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $199.00 

  • $459.00 

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  • Product Info
  • Antigen Details
  • Description
  • Application Note
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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous.
Gene : TYMS
Gene ID : 7298
Uniprot ID : P04818
Alternative Name : dTMP synthase, TMS, TS, TSase, TYMS protein, Tyms thymidylate synthetase
Immunogen Information : Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drµgs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

ELISA (For coating, order antibody without BSA); Flow Cytometry (0.5-1µg/million cells); Immunofluorescence (0.5-1µg/ml); Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody(Clone: rTYMS/1884)

Product code: 36-3324
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