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  7. Coronavirus (COVID-19/Sars-Cov-2/2019nCov) Spike biotinylated Antibody

Coronavirus (COVID-19/Sars-Cov-2/2019nCov) Spike biotinylated Antibody

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Fig.1: Wells of a 96-microtiter plate were coated with different concentration of a mammalian expressed full-length SARS-CoV-2 Spike protein. The binding was detected by addition of 200 ng of biotinylated anti-Spike S polyclonal antibody (Cat.# 11-2001-B) per well. The reactivity was detected by HRP-conjugated Streptavidin.

Coronavirus (COVID-19/Sars-Cov-2/2019nCov) Spike biotinylated Antibody

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Product code: 11-2001-B

Clonality : Polyclonal
Application : ELISA
Conjugate : Biotin

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Order now and get it on Tuesday June 06, 2023

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Local delivery areas

Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $220.00 

  • $380.00 

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Shipping Info:

Order now and get it on Tuesday June 06, 2023

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • Citations (1)
  • Review   (0)
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Purification
Content : 100 µg or 25 µg in PBS + 0.05% Azide
Storage condition : Store the antibody at 4°C, stable for 6 months. Avoid repeated freeze and thaw cycles.
Uniprot ID : P0DTC2
Alternative Name : nCov, Sars-Cov-2
Immunogen Information : A partial length recombinant coronavirus Spike Protein (amino acids 970-985) was used as the immunogen for this antibody.

The spike (S) protein of nCoV/SARS-CoV-2/COVID-19 is one of the structural glycoproteins that remains embedded in viral envelope and acts as the fundamental component of early viral infection of nCoV/SARS-CoV-2/COVID-19 upon binding the host receptor. The nCoV/SARS-CoV-2/COVID-19 has a trimeric spike protein which has two main domains such as S1 domain for receptor binding and S2 domain for membrane fusion and several specific cleavage sites in S1- S2 boundary junction that needs a novel, endocytic protease- primed cleavage to get activated during infection. It mainly binds to the furin protein on the cell membrane which performs trypsin like proteolytic cleavage and then the protein gets activated facilitating its entry into the host. This transmembrane spike protein of nCoV/SARS-CoV-2/COVID-19 shares binding property to the Angiotensin Converting Enzyme 2 (ACE2) likely to that of SARS- CoV. The high affinity of nCoV/SARS-CoV-2/COVID-19 Spike protein for human ACE2 may contribute to the apparent ease with which nCoV/SARS-CoV-2/COVID-19 can spread from human-to-human and make nCoV/SARS-CoV-2/COVID-19 pandemic.

1. Minimal system for assembly of SARS-CoV-2 virus like particles: Heather Swann, Abhimanyu Sharma, Benjamin Preece, Abby Peterson, Crystal Eldridge, David M. Belnap, Michael Vershinin, Saveez Saffarian bioRxiv 2020.06.01.128058; doi: https://doi.org/10.1101/2020.06.01.128058

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Coronavirus (COVID-19/Sars-Cov-2/2019nCov) Spike biotinylated Antibody

Product code: 11-2001-B
*specify in mg or ml

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