Monoclonal Antibody to TRIM29 (Lung Squamous Cell Carcinoma Marker)(Clone : MSVA-629M)
Figure 1: TRIM29 Antibody in Numerous Tissues (IHC) Tripartite motif-containing protein 29 Mouse Monoclonal Antibody (MSVA-629M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | IgG2b / Kappa |
| Purification : | Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide. |
| Content : | This antibody is available for research use only and is not approved for use in diagnosis. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| Gene : | TRIM29 |
| Gene ID : | 23650 |
| Uniprot ID : | Q14134 |
| Alternative Name : | Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, Ataxia telangiectasia group D complementing gene (ATDC); Tripartite motif-containing protein 29 (TRIM29); |
| Immunogen Information : | Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein |
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies. It plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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