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|Amount :||5 mg|
|Content :||E-64d is supplied as a crystalline solid.|
|Storage condition :||Store at -20°C, product is stable for at least two years.|
|Alternative Name :||Aloxistatin, E-64c ethyl ester,EP 453, EST, Loxistatin, NSC 694281|
Molecular Formula: C17H30N2O5
Molecular Weight: 342.4
Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways. E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases.E-64d inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. By disrupting protease activity, E-64d, at concentrations between 20-200 µM, has been shown to arrest human epidermoid carcinoma A431 cells at mitotic metaphase.It also inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 µM.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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