Monoclonal Antibody to Alpha-synuclein (Clone: 2A7)
Figure-1: Immunofluorescent analysis of rat cerebellum section stained with mouse mAb to α-synuclein (34-1110), dilution 1:1,000, in red, and costained with rabbit pAb to GFAP (34-1042) dilution 1:5,000 in green. The blue is Hoechst staining of nuclear DNA. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45μM, and free-floating sections were stained with above antibodies. The α-synuclein protein is concentrated in synaptic regions, while the GFAP antibody stains the filamentous cytoskeleton of Bergmann glia and astrocytic cells.
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG1 |
| Content : | Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
WB:1:1,000 IF/ICC: 1:1,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Membrane, Nucleus, Cell junction, Secreted |
| Post transnational modification: | Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. |
| Tissue Specificity: | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain. |
| BioGrid: | 112506. 474 interactions. |
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