Anti-BIN1 Monoclonal Antibody (Clone: 99D)(Discontinued)
Figure 1: Anti-BIN1 monoclonal antibody(39-1005) .Western blotting : Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Skeletal Muscle Tissue Lysate, Lane 3: Rat Heart Tissue Lysate, Lane 4: Rat Kidney Tissue Lysate.
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| Amount : | 100 μg/vial |
| Isotype : | Mouse IgG2b |
| Purification : | Ascites |
| Content : | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
BIN1(AMPH2) is a novel human gene product with features of a tumor suppressor protein. BIN1 gene to chromosome 2q14. Loss of BIN1 expression appears to be a frequent aberration in human hepatocellular carcinomas . mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the functional interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei.
Western blot : 0.25μg/ml; Immunohistochemistry(Frozen Section) : 0.5μg/ml; Immunocytochemistry : 1μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Phosphorylated by protein kinase C. |
| Tissue Specificity: | Isoform AMPH2-1 is expressed in brain, concentrated at nerve terminals. Isoform AMPH2-2 is widely expressed. |
| BioGrid: | 250629. 14 interactions. |
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