Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54) (BSA/AZIDE Free)
|Amount :||100 µg|
|Isotype :||Mouse IgG2a Kappa|
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS (sterile filtered), BSA, Glycerol and Sodium azide free.|
|Storage condition :||Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.|
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells, and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis-5-10 µg/ml; FACS: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.