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  7. Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM570)

Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM570)

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Formalin-fixed, paraffin-embedded human Tonsil stained with CD45 Monoclonal Antibody (SPM570).

Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM570)

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Product code: 36-1616

Clone name : SPM570
Clonality : Monoclonal
Application : FACS, IF, IHC
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $249.00 

  • $499.00 

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  • Product Info
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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PTPRC
Gene ID : 5788
Uniprot ID : P08575
Alternative Name : PTPRC, CD45
Immunogen Information : Isolated neoplastic cells from T cell lymphoma

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Membrane raft
Post transnational modification: Heavily N- and O-glycosylated.
Tissue Specificity: Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
BioGrid: 111752. 24 interactions.
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Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM570)

Product code: 36-1616
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