Monoclonal Antibody to HLA-DRB (MHC II)(Clone : HLA-DRB/1067)

Product code: 36-1236

Clone name : HLA-DRB/1067
Clonality : Monoclonal
Application : IHC, FACS, WB, IF
Reactivity : Human

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100 µg

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : HLA-DRB1
Gene ID : 3123
Uniprot ID : P01911
Alternative Name : HLA-DRB1, HLA-DRB2
Immunogen Information : Activated human peripheral blood mononuclear cells

This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Its epitope is different from that of MAb L243. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-4ug/ml); ,Western Blot (1-2ug/ml); ,Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus, Endosome membrane, Lysosome membrane, Late endosome membrane
Post transnational modification: Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.
BioGrid: 109368. 39 interactions.
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