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  7. Monoclonal Antibody to HMGB1 (Clone: ABM24C2)

Monoclonal Antibody to HMGB1 (Clone: ABM24C2)

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Fig-1: Western blot analysis of HMGB1. Anti- HMGB1 antibody (Clone: ABM24C2) was used at 2 µg/ml on HepG2 lysate.

Monoclonal Antibody to HMGB1 (Clone: ABM24C2)
Monoclonal Antibody to HMGB1 (Clone: ABM24C2)

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Fig-1: Western blot analysis of HMGB1. Anti- HMGB1 antibody (Clone: ABM24C2) was used at 2 µg/ml on HepG2 lysate.
Fig-2: Intracellular flow analysis of HMGB1 in PBMC (Lymphocytes) using 0.5 µg/10^6 cells of HMGB1 antibody (Clone: ABM24C2). Green represents isotype control; red represents anti-HMGB1 antibody. Goat anti-mouse PE conjugate was used as secondary.

Product code: 10-4023

Clone name : ABM24C2
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

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Order now and get it on Tuesday January 26, 2021

Same day delivery FREE on San Diego area orders placed by 1.00 PM

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Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $90.00 

  • $270.00 

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Shipping Info:

Order now and get it on Tuesday January 26, 2021

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Download TDS MSDS

  • Product Info
  • Antigen Details
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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : HMGB1
Gene ID : 3146
Uniprot ID : P09429
Alternative Name : HMGB1, HMG1
Immunogen Information : A partial length recombinant HMGB1 protein (amino acids 1- 200) was used as the immunogen for this antibody.

HMGB1 (High-mobility group protein B1) is a 25 kDa non-histone chromatin protein, secreted by immune cells through leaderless secretory pathway. HMGB1 supports transcription and also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 has the ability to bend DNA in order to facilitate binding of other proteins to the DNA. HMGB1 has one important role in V(D)J recombination where act as a cofactor of the RAG complex. HMGB1 stimulates a plethora of cellular responses like inflammation, attracting inflammatory cells, recruiting stem cells and promoting their proliferation. HMGB1 is highly expressed in human kidney, tonsils, adipose tissue, adrenal cortex and amniotic fluid.

Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Endosome, Endoplasmic reticulum-Golgi intermediate compartment
Post transnational modification: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance (PubMed:24474694). Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and proinflammatory activities (By similarity).
Tissue Specificity: Ubiquituous. Expressed in platelets (PubMed:11154118).
BioGrid: 109389. 98 interactions.
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Monoclonal Antibody to HMGB1 (Clone: ABM24C2)

Product code: 10-4023
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