NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)

Product code: 10-3029-NALE

Clone name : ABM4D70
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Mouse

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Price
100 µg
$290.00 

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Shipping Info:

Order now and get it on Wednesday December 11, 2024

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Format : Azide Free,Purified
Amount : 100 µg
Isotype : Rat IgG2a Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : Tlr9
Gene ID : 81897
Uniprot ID : Q9EQU3
Alternative Name : Tlr9
Immunogen Information : A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody.

Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and, ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure.

Western blot analysis: 2-4 µg/ml; FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle
Post transnational modification: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain (PubMed:18931679, PubMed:18820679). Cleavage requires UNC93B1 (PubMed:18820679). Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling (PubMed:21402738).
Tissue Specificity: Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.
BioGrid: 219897. 1 interactions.
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