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  7. NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)

NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)

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Fig-1: Western blot analysis of mTLR9. Anti-mTLR9 antibody (Clone: ABM4D70) was tested at 2 µg/ml on mouse Small Intestine lysate.

NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)
NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)

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Fig-1: Western blot analysis of mTLR9. Anti-mTLR9 antibody (Clone: ABM4D70) was tested at 2 µg/ml on mouse Small Intestine lysate.
Fig-2: Intracellular flow analysis of mTLR9 in mouse splenocytes using 0.5 µg/10^6 cells of mTLR9 antibody (Clone: ABM4D70). Green represents isotype control; red represents anti-mTLR9 antibody. Goat anti-Rat FITC conjugate was used as secondary.

Product code: 10-3029-NALE

Clone name : ABM4D70
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Mouse

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Order now and get it on Tuesday June 06, 2023

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Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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100 µg
$290.00 

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Shipping Info:

Order now and get it on Tuesday June 06, 2023

Same day delivery FREE on San Diego area orders placed by 1.00 PM

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  • Product Info
  • Antigen Details
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Format : Azide Free,Purified
Amount : 100 µg
Isotype : Rat IgG2a Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : Tlr9
Gene ID : 81897
Uniprot ID : Q9EQU3
Alternative Name : Tlr9
Immunogen Information : A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody.

Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and, ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure.

Western blot analysis: 2-4 µg/ml; FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle
Post transnational modification: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain (PubMed:18931679, PubMed:18820679). Cleavage requires UNC93B1 (PubMed:18820679). Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling (PubMed:21402738).
Tissue Specificity: Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.
BioGrid: 219897. 1 interactions.
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NALE™ Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70) (No Azide Low Endotoxin)

Product code: 10-3029-NALE
*specify in mg or ml

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