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  7. Monoclonal Antibody to Human TLR2 (Clone : TLR2.45)

Monoclonal Antibody to Human TLR2 (Clone : TLR2.45)

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Figure-1: Functional study experiment is showing the effect of anti-TLR2 antibodies on TNF production in whole blood model upon treatment with PAM3CSK4 at 300 ng/ml.

Monoclonal Antibody to Human TLR2 (Clone : TLR2.45)

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Product code: 10-3517

Clone name : TLR2.45
Clonality : Monoclonal
Application : Functional Assay, IP, FACS
Reactivity : Human

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  •   100 µg

  •  500 µg

  • $699.00 

  • $1,745.00 

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Format : Purified
Amount : 500 µg
Isotype : Mouse IgG1
Content : 0.5 mg, 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Storage condition : Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Gene : TLR2
Gene ID : 7097
Uniprot ID : O60603
Alternative Name : CD282, TIL4

The monoclonal antibody 10-3517 recognizes human TLR2 (CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and are implicated in the innate defense to many pathogens. Mammalian TLRs have been identified as type I transmembrane signaling receptors with pattern recognition capabilities. TLRs recognize pathogen-associated molecular patterns (PAMPs), expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Among TLRs, TLR2 is an unique receptor recognizing lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as peptidoglycan, lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282). TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Furthermore, TLR2 is detected in lung and fetal liver. In other tissues TLR2 levels are low. The TLR2.45 monoclonal antibody is generated using Ba/F3 cells which stably express human Flag-tagged TLR2.

Subcellular location: Membrane, Cytoplasmic vesicle, Membrane raft
Post transnational modification: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
Tissue Specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
BioGrid: 112952. 27 interactions.
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Monoclonal Antibody to Human TLR2 (Clone : TLR2.45)

Product code: 10-3517
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