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    7. Rabbit Polyclonal Antibody to Lamin A+C(Discontinued)

    Rabbit Polyclonal Antibody to Lamin A+C(Discontinued)

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    Figure-1 : Western blot analysis of Lamin A+C Antibody at 1 µg/ml on HeLa, A431, HepG2, LOVO, NIH/3T3 cell lysates, IRDye 800 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody.

    Rabbit Polyclonal Antibody to Lamin A+C(Discontinued)
    Rabbit Polyclonal Antibody to Lamin A+C(Discontinued)

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    Figure-1 : Western blot analysis of Lamin A+C Antibody at 1 µg/ml on HeLa, A431, HepG2, LOVO, NIH/3T3 cell lysates, IRDye 800 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody.
    Figure-2 : Flow cytometric analysis of Lamin A+C Antibody on HepG2 cells, Shaded histogram represents Lamin A+C Antibody and open histogram represents isotype control. PE conjugated anti-rabbit IgG used as secondary antibody.

    Product code: 45-1044

    Clonality : Polyclonal
    Application : ELISA
    Reactivity : Mouse, Human

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    For estimated delivery dates, please contact us at support@abeomics.com

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    • Product Info
    • Antigen Details
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    Format : Purified
    Amount : 100 µg
    Isotype : Rabbit IgG
    Purification : Immunoaffinity chromatography
    Content : 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
    Storage condition : The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
    Gene : LMNA
    Gene ID : 4000
    Uniprot ID : P02545
    Alternative Name : Lamin A/C antibody, Renal carcinoma antigen NY-REN-32
    Immunogen Information : KLH-coupled synthetic peptide within residues 400-450 of human Lamin A .

    Lamins are structural protein components of the nuclear lamina which contains 3 members: Lamin A, B and C in mammalian cells. Lamin A and lamin C are generated by alternative splicing from the same gene and share complete identity for the first 566 amino acids. Lamin A interacts with transcription factor SREBP1 via its C-terminal domain. The lamin A/C deficiency is probably associated with both defective nuclear mechanics and impaired transcriptional activation. The lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. Rabbit Anti-Lamin A+C Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 400-450 of human Lamin A (Swiss Prot: P02545).

    ELISA Capture: 0.5-10 µg/ml
    ELISA Detection: 0.05-0.2 µg/ml
    Western Blot: 1-2 µg/ml
    Flowcytometry analysis: 1-2 µg/10^6Cells

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Nucleus speckle
    Post transnational modification: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting.
    Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
    BioGrid: 110186. 661 interactions.
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    Rabbit Polyclonal Antibody to Lamin A+C(Discontinued)

    Product code: 45-1044
    *specify in mg or ml

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