Recombinant Human Asialoglycoprotein Receptor Protein/ASGPR1 (C-His)
|Amount :||50 µg|
|Content :||Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.2|
|AA sequence :||Recombinant Human Asialoglycoprotein Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln62-Ile291 is expressed with a 6His tag at the C-terminus.|
|Alternative Name :||Asialoglycoprotein Receptor 1; ASGP-R 1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; HL-1; ASGR1; CLEC4H1|
The asialoglycoprotein receptor (ASGPR) is an endocytotic cell surface receptor that is a member of the long-form subfamily of the C-type/Ca2+ dependent lectin family. ASGPR is expressed by hepatocytes and a subset of T cells and can be induced by triantennary binding to galactose residues of macromolecules. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR is reported to bind Gal (nonreducing), GalNAc, and sialic acid alpha 2,6Gal and GalNAc. Studies found that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.