Anti-Catenin, gamma (Cardiomyocyte Marker) Monoclonal Antibody(Clone: 11E4)
Fig. 1: Western Blot of HT20, A549, 293 and A431 cell lysates using C Catenin, gamma Mouse Monoclonal Antibody (11E4).
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | JUP |
| Gene ID : | 3728 |
| Uniprot ID : | P14923 |
| Alternative Name : | ARVD12; Catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; Junction Plakoglobin; PDGB; PKGB |
| Immunogen Information : | Recombinant full length human plakoglobin, fused to maltose binding protein |
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
Flow Cytometry (1-2ug/million cells); ,Immunofluorescence (1-2ug/ml); ,Western Blot (1-2ug/ml);,
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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