Anti-Catenin, gamma (Cardiomyocyte Marker) Monoclonal Antibody(Clone: 11E4)
|Amount :||100 µg|
|Isotype :||Mouse IgG1, kappa|
|Content :||200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage condition :||Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.|
|Gene ID :||3728|
|Uniprot ID :||P14923|
|Alternative Name :||ARVD12; Catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; Junction Plakoglobin; PDGB; PKGB|
|Immunogen Information :||Recombinant full length human plakoglobin, fused to maltose binding protein|
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
Flow Cytometry (1-2ug/million cells); ,Immunofluorescence (1-2ug/ml); ,Western Blot (1-2ug/ml);,
For Research Use Only. Not for use in diagnostic/therapeutics procedures.