Anti-CD11b activation epitope Monoclonal Antibody (Clone:CBRM1/5)
|Purified by protein-A affinity chromatography
|Storage condition :
|Store at 2-8°C. Do not freeze.
|Immunogen Information :
|Information not available
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
Flow Cytometry Immunoprecipitation Functional Application blocking
For Research Use Only. Not for use in diagnostic/therapeutics procedures.