Anti-Cytokeratin 18 Monoclonal Antibody (Clone:IHC018)
Figure 1: Immunohistochemical analysis of Cytokeratin 18 (Clone: IHC018) on Colon - 10X
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse lgG2b, kappa |
| Purification : | Protein A/G Chromatography |
| Content : | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage condition : | Store at 2°C - 8°C. Do not freeze. |
Cytokeratin 18 (CK18) is present in simple, glandular, and transitional epithelial cells, but is absent in stratified epithelial cells. CK18 usually multimerizes with Cytokeratin 8, and Anti-Cytokeratin 18 is useful for detecting adenocarcinomas of simple and glandular epithelium origin, as well as poorly differentiated squamous carcinoma cells.
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. |
| Tissue Specificity: | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
| BioGrid: | 110073. 113 interactions. |
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