Anti-Human CD264 APC (Clone : TRAIL-R4-01)
Figure 1 : Flow cytometry surface staining pattern of CD264 transfected HEK-293 cells using anti-human CD264 (TRAIL-R4-01) APC (concentration in sample 1,67 µg/ml).
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Content : | 0.1 mg/ml Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
| Gene : | TNFRSF10D |
| Gene ID : | 8793 |
| Alternative Name : | TNFRSF10D, DcR2, TRUNDD, TRAILR4,TNF receptor superfamily member 10d |
| Immunogen Information : | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Specificity : The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Specificity : The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
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