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  7. Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)

Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)

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Fig. 1: Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MSH2 Mouse Monoclonal Antibody (MSH2/2622).

Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)
Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)
Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)
Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)
Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)
Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)

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Fig. 1: Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MSH2 Mouse Monoclonal Antibody (MSH2/2622).
Fig. 2: Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with MSH2 Mouse Monoclonal Antibody (MSH2/2622).
Fig. 3: Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with MSH2 Mouse Monoclonal Antibody (MSH2/2622).
Fig. 4: Western Blot Analysis of human HepG2, A549, and A431 cell lysate using MSH2 Mouse Monoclonal Antibody (MSH2/2622).
Fig. 5: Flow Cytometric Analysis of A549 cells using MSH2 Mouse Monoclonal Antibody (MSH2/2622) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Fig. 6: SDS-PAGE Analysis of Purified MSH2 Mouse Monoclonal Antibody (MSH2/2622). Confirmation of Purity and Integrity of Antibody

Product code: 36-2801

Clone name : MSH2/2622
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $199.00 

  • $459.00 

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  • Product Info
  • Antigen Details
  • Description
  • Application Note
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Amount : 100 µg
Isotype : Mouse IgG1, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : MSH2
Gene ID : 4436
Uniprot ID : P43246
Alternative Name : BAT26; COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC1; LCFS2; MSH2; MutS homolog 2; MutS homolog 2 colon cancer nonpolyposis type 1; MutS protein homolog 2
Immunogen Information : Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to sµggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

Flow Cytometry (1-2µg/million cells); Western Blot (1-2µg/ml);Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-MSH2 (DNA Mismatch Repair Marker) Monoclonal Antibody(Clone: MSH2/2622)

Product code: 36-2801
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